A Step-by-Step Guide Using JMP

Author: Ronald Snee,Roger Hoerl

Publisher: SAS Institute

ISBN: 1629605301

Category: Computers

Page: 294

View: 8809

Strategies for Formulations Development: A Step-by-Step Guide Using JMP is based on the authors' significant practical experience partnering with scientists to develop strategies to accelerate the formulation (mixtures) development process. The authors not only explain the most important methods used to design and analyze formulation experiments, but they also present overall strategies to enhance both the efficiency and effectiveness of the development process. With this book you will be able to: Approach the development process from a strategic viewpoint with the overall end result in mind. Design screening experiments to identify components that are most important to the performance of the formulation. Design optimization experiments to identify the maximum response in the design space. Analyze both screening and optimization experiments using graphical and numerical methods. Optimize multiple criteria, such as the quality, cost, and performance of product formulations. Design and analyze formulation studies that involve both formulation components and process variables using methods that reduce the required experimentation by up to 50%. Linking dynamic graphics with powerful statistics, JMP helps construct a visually compelling narrative to interactively share findings that are coherent and actionable by colleagues and decision makers. Using this book, you can take advantage of computer generated experiment designs when classical designs do not suffice, given the physical and economic constraints of the experiential environment. Strategies for Formulations Development: A Step-by-Step Guide Using JMP(R) is unique because it provides formulation scientists with the essential information they need in order to successfully conduct formulation studies in the chemical, biotech, and pharmaceutical industries.
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Finding the Sweet Spot through Design and Analysis of Experiments with Mixtures

Author: Mark J. Anderson,Patrick J. Whitcomb,Martin A. Bezener

Publisher: Taylor & Francis

ISBN: 1351677519

Category: Business & Economics

Page: 209

View: 5385

Many chemists – especially those most brilliant in their field – fail to appreciate the power of planned experimentation. They dislike the mathematical aspects of statistical analysis. In addition, these otherwise very capable chemists also dismissed predictive models based only on empirical data. Ironically, in the hands of subject matter experts like these elite chemists, the statistical methods of mixture design and analysis provide the means for rapidly converging on optimal compositions. What differentiates Formulation Simplified from the standard statistical texts on mixture design is that the authors make the topic relatively easy and fun to read. They provide a whole new collection of insighful original studies that illustrate the essentials of mixture design and analysis. Solid industrial examples are offered as problems at the end of many chapters for those who are serious about trying new tools on their own. Statistical software to do the computations can be freely accessed via a web site developed in support of this book.
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Improving Business Performance

Author: Roger Hoerl,Ron D. Snee

Publisher: John Wiley & Sons

ISBN: 1118094778

Category: Business & Economics

Page: 544

View: 9915

How statistical thinking and methodology can help you make crucial business decisions Straightforward and insightful, Statistical Thinking: Improving Business Performance, Second Edition, prepares you for business leadership by developing your capacity to apply statistical thinking to improve business processes. Unique and compelling, this book shows you how to derive actionable conclusions from data analysis, solve real problems, and improve real processes. Here, you'll discover how to implement statistical thinking and methodology in your work to improve business performance. Explores why statistical thinking is necessary and helpful Provides case studies that illustrate how to integrate several statistical tools into the decision-making process Facilitates and encourages an experiential learning environment to enable you to apply material to actual problems With an in-depth discussion of JMP® software, the new edition of this important book focuses on skills to improve business processes, including collecting data appropriate for a specified purpose, recognizing limitations in existing data, and understanding the limitations of statistical analyses.
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A Step-by-step Guide Based on Experience with GE and Other Six Sigma Companies

Author: Ronald D. Snee,Roger Wesley Hoerl

Publisher: FT Press

ISBN: 9780130084576

Category: Business & Economics

Page: 279

View: 1975

Leading Six Sigmais the complete guide to leading quality initiatives in your company. Top Six Sigma consultant Ronald Snee and GE quality leader Roger Hoerl demonstrate how to deploy a Six Sigma plan that reflects your unique organization, and key lessons learned from the world's best implementations. Coverage includes every facet of Six Sigma leadership: strategy, goal setting, metrics, training, roles/responsibilities, processes, reporting, rewards, ongoing review, and much more.
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Author: SAS

Publisher: SAS Institute

ISBN: 1629609455

Category: Computers

Page: 694

View: 5659

The JMP 13 Design of Experiments Guide covers classic DOE designs (for example, full factorial, response surface, and mixture designs). Read about more flexible custom designs, which you generate to fit your particular experimental situation. And discover JMP’s definitive screening designs, an efficient way to identify important factor interactions using fewer runs than required by traditional designs. The book also provides guidance on determining an appropriate sample size for your study.
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A Practical Guide, Second Edition

Author: Alex Dmitrienko,Gary G. Koch

Publisher: SAS Institute

ISBN: 1635261449

Category: Computers

Page: 410

View: 2972

Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.
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Deployment Strategies for Financial Services, Health Care, and the Rest of the Real Economy

Author: Ron D. Snee,Roger W. Hoerl

Publisher: Ft Press

ISBN: 9780137145355

Category: Business & Economics

Page: 326

View: 6248

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JMP

Statistics and Graphics Guide

Author: N.A

Publisher: Sas Inst

ISBN: 9781580256315

Category: Computers

Page: 159

View: 2325

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Author: Feroz Jameel,Susan Hershenson,Mansoor A. Khan,Sheryl Martin-Moe

Publisher: Springer

ISBN: 1493923161

Category: Medical

Page: 710

View: 7315

This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These chapters also discuss lessons learned from the FDA Office of Biotechnology Products pilot program. Following chapters demonstrate how QbD is used for formulation development ranging from screening of formulations to developability assessment to development of lyophilized and liquid formats. The next few chapters study the use of small-scale and surrogate models as well as QbD application to drug product processes such as drug substance freezing and thawing, mixing, sterile filtration, filling, lyophilization, inspection and shipping and handling. Later chapters describe more specialized applications of QbD in the drug product realm. This includes the use of QbD in primary containers, devices and combination product development. The volume also explores QbD applied to vaccine development, automation, mathematical modeling and monitoring, and controlling processes and defining control strategies. It concludes with a discussion on the application of QbD to drug product technology transfer as well as overall regulatory considerations and lifecycle management. Quality by Design for Biopharmaceutical Drug Product Development is an authoritative resource for scientists and researchers interested in expanding their knowledge on QbD principles and uses in creating better drugs.
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An Experiment

Author: Timothy Goodman,Jessica Walsh

Publisher: ABRAMS

ISBN: 1613127154

Category: Self-Help

Page: 304

View: 547

“What would happen if Harry met Sally in the age of Tinder and Snapchat? . . . A field guide to Millennial dating in New York City” (New York Daily News). When New York–based graphic designers and long-time friends Timothy Goodman and Jessica Walsh found themselves single at the same time, they decided to try an experiment. The old adage says that it takes 40 days to change a habit—could the same be said for love? So they agreed to date each other for 40 days, record their experiences in questionnaires, photographs, videos, texts, and artworks, and post the material on a website they would create for this purpose. What began as a small experiment between two friends became an Internet sensation, drawing 5 million unique (and obsessed) visitors from around the globe to their site and their story. 40 Days of Dating: An Experiment is a beautifully designed, expanded look at the experiment and the results, including a great deal of material that never made it onto the site, such as who they were as friends and individuals before the 40 days and who they have become since.
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The Hardware Software Interface

Author: David A. Patterson,John L. Hennessy

Publisher: Morgan Kaufmann

ISBN: 0128122765

Category: Computers

Page: 696

View: 6582

The new RISC-V Edition of Computer Organization and Design features the RISC-V open source instruction set architecture, the first open source architecture designed to be used in modern computing environments such as cloud computing, mobile devices, and other embedded systems. With the post-PC era now upon us, Computer Organization and Design moves forward to explore this generational change with examples, exercises, and material highlighting the emergence of mobile computing and the Cloud. Updated content featuring tablet computers, Cloud infrastructure, and the x86 (cloud computing) and ARM (mobile computing devices) architectures is included. An online companion Web site provides advanced content for further study, appendices, glossary, references, and recommended reading. Features RISC-V, the first such architecture designed to be used in modern computing environments, such as cloud computing, mobile devices, and other embedded systems Includes relevant examples, exercises, and material highlighting the emergence of mobile computing and the cloud
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Challenges and Strategies for Sample Preparation and Extraction

Author: Beverly Nickerson

Publisher: Springer Science & Business Media

ISBN: 9781441996312

Category: Medical

Page: 397

View: 2332

This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. This book is divided into four parts: • Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. • Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms. • Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods. • Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.
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An Illustrated Step-by-Step Guide for New Users, Second Edition

Author: Curt Hinrichs,Chuck Boiler

Publisher: SAS Institute

ISBN: 1629592889

Category: Mathematics

Page: 358

View: 9009

Grasp essential steps in order to generate meaningful results quickly with JMP. JMP Essentials: An Illustrated Step-by-Step Guide for New Users, Second Edition is designed for the new or occasional JMP user who needs to generate meaningful graphs or results quickly. Drawing on their own experience working with these customers, the authors provide essential steps for what new users typically need to carry out with JMP. This newest edition has all new instructions and screen shots reflecting the latest release of JMP software. In addition, it has eight new detailed sections and 10 new subsections that include creating maps, filtering data, creating dashboards, and working with Excel data, all of which highlight new, useful and basic level enhancements to JMP. The format of the book is unique. It adopts a show-and-tell design with essential step-by-step instructions and corresponding screen illustrations, which help users quickly see how to generate the desired results. In most cases, each section completes a JMP task, which maximizes the book's utility as a reference. In addition, each chapter contains a family of features that are carefully crafted to first introduce you to basic features and then on to more advanced ones. JMP Essentials: An Illustrated Step-by-Step Guide for New Users, Second Edition is the quickest and most accessible reference book available. This is part of the SAS Press program.
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Author: Heath Rushing,Andrew Karl,James Wisnowski

Publisher: SAS Institute

ISBN: 1612908012

Category: Mathematics

Page: 302

View: 1766

With a growing number of scientists and engineers using JMP software for design of experiments, there is a need for an example-driven book that supports the most widely used textbook on the subject, Design and Analysis of Experiments by Douglas C. Montgomery. Design and Analysis of Experiments by Douglas Montgomery: A Supplement for Using JMP meets this need and demonstrates all of the examples from the Montgomery text using JMP. In addition to scientists and engineers, undergraduate and graduate students will benefit greatly from this book. While users need to learn the theory, they also need to learn how to implement this theory efficiently on their academic projects and industry problems. In this first book of its kind using JMP software, Rushing, Karl and Wisnowski demonstrate how to design and analyze experiments for improving the quality, efficiency, and performance of working systems using JMP. Topics include JMP software, two-sample t-test, ANOVA, regression, design of experiments, blocking, factorial designs, fractional-factorial designs, central composite designs, Box-Behnken designs, split-plot designs, optimal designs, mixture designs, and 2 k factorial designs. JMP platforms used include Custom Design, Screening Design, Response Surface Design, Mixture Design, Distribution, Fit Y by X, Matched Pairs, Fit Model, and Profiler. With JMP software, Montgomery’s textbook, and Design and Analysis of Experiments by Douglas Montgomery: A Supplement for Using JMP, users will be able to fit the design to the problem, instead of fitting the problem to the design. This book is part of the SAS Press program.
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A Guide to Best Practice

Author: Joachim Ermer,Phil W. Nethercote

Publisher: John Wiley & Sons

ISBN: 3527672184

Category: Medical

Page: 440

View: 4311

This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.
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Author: John A. Cornell

Publisher: John Wiley & Sons

ISBN: 0470907428

Category: Mathematics

Page: 368

View: 6358

The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.
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Author: Ron D. Snee,Roger Hoerl

Publisher: FT Press

ISBN: 0134288904

Category: Business & Economics

Page: 384

View: 9114

A Holistic Approach to Performance Improvement That Reflects 30 Years of Six Sigma Learning Leading Holistic Improvement with Lean Six Sigma 2.0 distills all that’s been learned about Six Sigma over the past three decades, helping you build and execute on modern holistic strategies to radically improve processes and performance. It’s the definitive modern guide to Lean Six Sigma for executives, champions, Black Belts, Green Belts, and every stakeholder concerned with performance improvement. In addition, it notes the limitations of Lean Six Sigma and explains how to broaden deployments to true holistic improvement, integrating multiple improvement methodologies. Renowned experts Ronald Snee and Roger Hoerl help you launch or accelerate comprehensive “Lean Six Sigma 2.0” initiatives, integrating modern techniques to improve customer satisfaction, employee engagement, growth, and profitability across your organization. They introduce important recent advances in Lean Six Sigma theory and practice, and offer new case studies illuminating opportunities for holistic improvement. With an ideal mix of fundamental concepts and real-world case studies, the authors help you broaden your portfolio of improvement methodologies, integrating systems for process management, control, and risk management. This revision incorporates decades of collective experience in improvement initiatives, the most relevant research on what does and doesn’t work, and contains three completely new chapters, as well as two previously unpublished holistic improvement case studies. This innovative approach is specifically designed to help you solve large, complex, and unstructured problems; and manage risk in a world of cyberattacks, terrorism, and fragmentation. Plan and deploy a modern Lean Six Sigma strategy that fully reflects your organization Learn and apply key lessons from the world’s best implementations Integrate key success factors into a step-by-step process for improvement, and avoid common pitfalls that lead to failure Master all facets of Lean Six Sigma leadership, including strategy, goal setting, metrics, training, roles/responsibilities, processes, reporting, rewards, and ongoing management review Evolve your deployment to true holistic improvement that leverages modern methods and encompasses the entire organization Make the most of big data analytics and other modern methods Choose the optimal improvement method for each complex challenge you face Use a focus on improvement as a leadership development tool
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Librarians, Data, and the Education of a New Generation of Researchers

Author: Jake Carlson,Lisa R. Johnston

Publisher: Purdue University Press

ISBN: 1557536961

Category: Language Arts & Disciplines

Page: 271

View: 7804

Data information literacy is introduced as a new area of opportunity for librarians seeking to educate the next generation of scholars about best practices when working with research data in a way that is sustainable over the long term.
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FMEA from Theory to Execution

Author: D. H. Stamatis

Publisher: ASQ Quality Press

ISBN: 0873895983

Category: Science

Page: 488

View: 9157

Author D. H. Stamatis has updated his comprehensive reference book on failure mode and effect analysis (FMEA). This is one of the most comprehensive guides to FMEA and is excellent for professionals with any level of understanding. This book explains the process of conducting system, design, process, service, and machine FMEAs, and provides the rationale for doing so. Readers will understand what FMEA is, the different types of FMEA, how to construct an FMEA, and the linkages between FMEA and other tools. Stamatis offer a summary of tools/methodologies used in FMEA along with a glossary to explain key terms and principles. the updated edition includes information about the new ISO 9000:2000 standard, the Six Sigma approach to FMEA, a special section on automotive requirements related to ISO/TS 16949, the orobustnesso concept, and TE 9000 and the requirements for reliability and maintainability. the accompanying CD-ROM offers FMEA forms and samples, design review checklist, criteria for evaluation, basic reliability formulae and conversion failure factors, guidelines for RPN calculations and designing a reasonable safe product, and diagrams, and examples of FMEAs with linkages to robustness.
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Author: Marsha Linehan

Publisher: Guilford Publications

ISBN: 1462516998

Category: Psychology

Page: 504

View: 9123

Preceded by: Skills training manual for treating borderline personality disorder / Marsha M. Linehan. c1993.
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