From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug

Author: Thomas Hager

Publisher: Broadway Books

ISBN: 0307352285

Category: Science

Page: 384

View: 896

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . . But all that was about to change. . . . —from The Demon Under the Microscope From the Hardcover edition.
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Kulturgeschichten vom menschlichen Körper

Author: Hugh Aldersey-Williams

Publisher: Carl Hanser Verlag GmbH Co KG

ISBN: 3446436391

Category: Science

Page: 358

View: 1464

Unser Körper: Wir sprechen ständig über ihn. Er inspiriert uns zu großer Kunst, er beschäftigt die Wissenschaft, und die spannendsten Geschichten drehen sich um ihn. Er ist der Quell aller Vergnügungen. Doch erst wenn wir krank werden, wird uns das komplizierte Gebilde aus Fleisch, Knochen und Flüssigkeiten wirklich bewusst. Auf der Suche nach Kulturgeschichten vom Körper begibt sich Hugh Aldersey-Williams auf einen Streifzug durch Naturwissenschaft, Kunst, Literatur und Alltag. Das Buch des Bestsellerautors aus Großbritannien ist eine Schatzkammer überraschender Fakten und Anekdoten – über die Physiologie der Engel, elektrische Knochen und den wahren Sitz der Seele: in der Leber.
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The Improbable Quest to Discover New Medicines

Author: Donald R. Kirsch,Ogi Ogas

Publisher: Simon and Schuster

ISBN: 1628727195

Category: Science

Page: 328

View: 356

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
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Author: Sergio Sanchez

Publisher: Caister Academic Press

ISBN: 190823055X

Category: Medical

Page: 442

View: 1592

The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in human- and animal-health and the associated dramatic increase in human life expectancies. Indeed the possibility of eradicating infectious disease seemed feasible. However it soon became apparent that microorganisms wouldn't be defeated so easily. Their weapon: antibiotic resistance. Today microbial antibiotic resistance is rapidly exhausting our supply of effective compounds and making the possibility of a global public health disaster seems likely. The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents. In this timely book respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic', explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. This book is essential reading for everyone working in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries.
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Author: Dennis A. Connole

Publisher: McFarland

ISBN: 1476675430

Category: Argonne, Battle of the, France, 1918

Page: 254

View: 6633

"Immigrant American soldiers played an important role in World War I. Matthew Guerra (the author's great uncle) immigrated to America from Italy around age 12. He was drafted into the U.S. Army in 1918 and shipped to France, where he joined the 58th Infantry Regiment of the 4th "Ivy" Division. Wounded by shrapnel, the 22-year-old died"--
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Author: John R. Weeks

Publisher: Cengage Learning

ISBN: 1305545095

Category: Social Science

Page: 608

View: 8739

John R. Weeks's POPULATION introduces students to population issues, concepts, and theories by encompassing the entire field of demography, including both principle and practice. From fertility and mortality rates to agricultural production and urbanization, Weeks consistently engages students through compelling writing, comprehensive explication, and intriguing essays-giving students their best opportunity to truly master core demographic concepts. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
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Author: Yuval Noah Harari

Publisher: DVA

ISBN: 364110498X

Category: History

Page: 528

View: 4495

Krone der Schöpfung? Vor 100 000 Jahren war der Homo sapiens noch ein unbedeutendes Tier, das unauffällig in einem abgelegenen Winkel des afrikanischen Kontinents lebte. Unsere Vorfahren teilten sich den Planeten mit mindestens fünf weiteren menschlichen Spezies, und die Rolle, die sie im Ökosystem spielten, war nicht größer als die von Gorillas, Libellen oder Quallen. Vor 70 000 Jahren dann vollzog sich ein mysteriöser und rascher Wandel mit dem Homo sapiens, und es war vor allem die Beschaffenheit seines Gehirns, die ihn zum Herren des Planeten und zum Schrecken des Ökosystems werden ließ. Bis heute hat sich diese Vorherrschaft stetig zugespitzt: Der Mensch hat die Fähigkeit zu schöpferischem und zu zerstörerischem Handeln wie kein anderes Lebewesen. Anschaulich, unterhaltsam und stellenweise hochkomisch zeichnet Yuval Harari die Geschichte des Menschen nach und zeigt alle großen, aber auch alle ambivalenten Momente unserer Menschwerdung.
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A Selection Guide

Author: Raymond W. Barber,Patrice Bartell

Publisher: Hw Wilson Co

ISBN: 9780824210861

Category: Best books

Page: 1456

View: 1583

- More than 6,500 books in the initial clothbound volume, plus more than 2,400 new titles in four annual supplements. - New coverage of biographies, art, sports, Islam and the Middle East, and cultural diversity. - Special focus on graphic novels, primary source materials, nonbook materials, and periodicals. - Analytic entries for items in collections and anthologies.
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A Selection Guide to Reference Books and Adult Nonfiction. Nonfiction

Author: John Greenfieldt,Patrice Bartell

Publisher: Hw Wilson Co

ISBN: 9780824210946

Category: Public libraries

Page: 1856

View: 546

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Author: Carl Leon Bankston

Publisher: Salem PressInc

ISBN: 9781587654695

Category: History

Page: 1259

View: 545

The latest edition in the overwhelmingly popular Great Events from History series, Modern Scandals examines over 400 of the most important and most publicized scandals throughout the world since the beginning of the twentieth century. The essays in this set are 3-5 pages long and follow the same reader-friendly format that users have come to expect from the Great Events from History series.
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Roman

Author: Khaled Hosseini

Publisher: ebook Berlin Verlag

ISBN: 3827070236

Category: Fiction

Page: 384

View: 8534

Drachenläufer erzählt vom Schicksal der beiden Jungen Amir und Hassan und ihrer ungücklichen Freundschaft. Eine dramatische Geschichte von Liebe und Verrat, Trennung und Wiedergutmachung vor dem Hintergrund der jüngsten Vergangenheit Afghanistans.
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Roman

Author: Sinclair Lewis

Publisher: Aufbau Digital

ISBN: 3841213731

Category: Fiction

Page: 448

View: 7874

Sinclair Lewis’ Roman aus dem Jahr 1935 führt einen Antihelden vor, der mit seinen Hetzreden die Begeisterung unzufriedener Wähler entfacht. Durch seine Lügen und eine Rhetorik des Populismus und der Ressentiments wird er Präsident der Vereinigten Staaten. Das klingt vertraut? „Eine unheimliche Vorwegnahme der aktuellen Ereignisse.“ The Guardian „Ein Populist im Weißen Haus? Literaturnobelpreisträger Sinclair Lewis hat es vor 80 Jahren durchgespielt.“ DIE ZEIT „Sinclair Lewis ist wieder aktuell.“ der Freitag „Ein Meister des absoluten Realismus." Bob Dylan 1935 in den USA ein aufsehenerregender Bestseller, heute wieder eine Sensation und aktuell wie selten zuvor. In der Übersetzung des bekannten Exilautors und Kleist-Preis-Trägers Hans Meisel – mit einem Nachwort von Jan Brandt. Sinclair Lewis wusste durch seine Frau Dorothy Thompson, Auslandskorrespondentin in Berlin, über den Aufstieg der Nazis Bescheid. In den USA beobachtete er, wie die Populisten nach Wirtschaftskrise und Sozialreformen des New Deal immer weiter an Einfluss gewannen. Der radikale Senator Huey Long versuchte Präsident Roosevelt aus dem Amt zu drängen, bevor Long 1935 einem Attentat zum Opfer fiel. Lewis diente er als Vorbild für den fanatischen Verführer Buzz Windrip in seinem Roman. Buzz Windrip, für seine Gegner ein „ungebildeter Lügner mit idiotischer Weltanschauung“ und ein gefährlicher Populist, will Präsidentschaftskandidat werden. Er gibt vor, sich für die kleinen Leute einzusetzen, und verspricht, „aus Amerika wieder ein stolzes Land zu machen“. Trotz völlig unglaubwürdiger Versprechen laufen ihm die Wähler zu, und er zieht ins Weiße Haus ein. Sogleich regiert er wie ein absolutistischer Herrscher, beschneidet die Freiheiten der Minderheiten, legt sich mit Mexiko an und lässt seine Kritiker rabiat verfolgen. Einer davon ist der liberale Zeitungsherausgeber Doremus Jessup, der sich nicht mundtot machen lassen will.
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Author: N.A

Publisher: N.A

ISBN: N.A

Category: Communication in science

Page: N.A

View: 7793

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Publication of the Association of College and Research Libraries, a Division of the American Library Association

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Academic libraries

Page: N.A

View: 1292

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